反应详情

温度

100 °C

3-Bromo-4-fluoro-benzaldehyde (5.0 g, 24.6 mmol), malonic acid (5.6 g, 53.7 mmol), and piperidine (0.5 mL, 4.9 mmol) were added to pyridine (11.4 mL). The reaction mixture was stirred at 100° C. for 3 hours and then concentrated under reduced pressure. Distilled water was added to the reaction mixture, which was then filtered. The resulting solid was recrystallized from ethanol to give 3.3 g of the titled compound as a white solid.

1. concentrationconcentrated under reduced pressure
2. additionDistilled water was added to the reaction mixture, which
3. filtrationwas then filtered
4. customThe resulting solid was recrystallized from ethanol