反应详情

To a mixture of 3′-ethoxy-biphenyl-4-carbaldehyde (4.6 g, 20.1 mmol) prepared in Step 1 and pyruvic acid (1.7 mL, 24.1 mmol) in methanol (15.0 mL), was slowly added a solution of potassium hydroxide (2.0 g, 36.2 mmol) in methanol (15.0 mL) at 0° C. The reaction mixture was stirred at room temperature for 7 hours and then filtered. The resulting solid was diluted with a 1N hydrochloric acid solution and then extracted with ethyl acetate. The extract was washed with distilled water and brine, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give 2.5 g of the titled compound as a brown liquid.

1. filtrationfiltered
2. additionThe resulting solid was diluted with a 1N hydrochloric acid solution
3. extractionextracted with ethyl acetate
4. washThe extract was washed with distilled water and brine
5. dry with materialdried on anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure