HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 118431831, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 118432010 | HCID 118432010 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 118431831 | HCID 118431831 | 105.1% |
Reaction Steps
5-[2-(1-BOC-1,2,3,6-tetrahydropyridin-4-yl)-pyridin-6-yl]-1-(2-chloro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (280.0 mg, 0.50 mmol) prepared in Example 155 and trifluoroacetic acid (400.0 uL, 5.0 mmol) were added at 0° C. to dichloromethane (3.0 mL). The reaction mixture was stirred at room temperature for 1 hour and then concentrated under reduced pressure to give 300.0 mg of the titled compound as a yellow liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376420B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-df71cf52a0e841418c6f6ec07dfa4d8a |
| Source note | uspto-grants-2016_06 |