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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2208006Generated: November 2, 2026

Trifluoroacetic acid → HCID 118431831, compound

https://huagongshe.com/reaction/2208006

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 118432010HCID 118432010—
SolventDichloromethaneHCID 6344—
ProductHCID 118431831HCID 118431831105.1%

Reaction Steps

5-[2-(1-BOC-1,2,3,6-tetrahydropyridin-4-yl)-pyridin-6-yl]-1-(2-chloro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (280.0 mg, 0.50 mmol) prepared in Example 155 and trifluoroacetic acid (400.0 uL, 5.0 mmol) were added at 0° C. to dichloromethane (3.0 mL). The reaction mixture was stirred at room temperature for 1 hour and then concentrated under reduced pressure to give 300.0 mg of the titled compound as a yellow liquid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09376420B2
Source datasetuspto-grants-2016_06
ORD IDord-df71cf52a0e841418c6f6ec07dfa4d8a
Source noteuspto-grants-2016_06