Trifluoroacetic acid → HCID 118431831, compound

HRID 2208006Notes

Reaction equation

HRID 2208006 reaction equation
C([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH:20]3[N:24]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[Cl:31])[N:23]=[C:22]([C:32]([F:38])([F:37])[C:33]([F:36])([F:35])[F:34])[CH2:21]3)[N:15]=2)[CH2:10][CH2:9]1)(OC(C)(C)C)=O.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>ClCCl>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[Cl:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[N:24]1[CH:20]([C:16]2[N:15]=[C:14]([C:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=3)[CH:19]=[CH:18][CH:17]=2)[CH2:21][C:22]([C:32]([F:38])([F:37])[C:33]([F:35])([F:34])[F:36])=[N:23]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118432010HCID 118432010, compound

Product 1

HCID 118431831HCID 118431831, compoundYield 105.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-[2-(1-BOC-1,2,3,6-tetrahydropyridin-4-yl)-pyridin-6-yl]-1-(2-chloro-phenyl)-3-pentafluoroethyl-4,5-dihydro-1H-pyrazole (280.0 mg, 0.50 mmol) prepared in Example 155 and trifluoroacetic acid (400.0 uL, 5.0 mmol) were added at 0° C. to dichloromethane (3.0 mL). The reaction mixture was stirred at room temperature for 1 hour and then concentrated under reduced pressure to give 300.0 mg of the titled compound as a yellow liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-df71cf52a0e841418c6f6ec07dfa4d8a
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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