Trifluoroacetate → HCID 118432039, compound

HRID 2208084Notes

Reaction equation

HRID 2208084 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH2:21][CH2:22][N:23](C(OC(C)(C)C)=O)[CH2:24][CH:25]=3)=[CH:16][CH:15]=2)[CH2:12][C:11]([C:33]([C:39]([F:42])([F:41])[F:40])([C:35]([F:38])([F:37])[F:36])[OH:34])=[N:10]1.[F:43][C:44]([F:49])([F:48])[C:45]([O-:47])=[O:46]>ClCCl>[F:43][C:44]([F:49])([F:48])[C:45]([OH:47])=[O:46].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH:13]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH2:21][CH2:22][NH:23][CH2:24][CH:25]=3)=[CH:16][CH:15]=2)[CH2:12][C:11]([C:33]([C:39]([F:40])([F:41])[F:42])([C:35]([F:36])([F:37])[F:38])[OH:34])=[N:10]1

Participants

4

Reactant 2

HCID 84468TrifluoroacetateHCID 118431710HCID 118431710, compound

Product 1

HCID 118432039HCID 118432039, compoundYield 97.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(2,4-Difluoro-phenyl)-5-[4-(1-BOC-1,2,3,6-tetrahydropyridin-4-yl)-phenyl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole (800.0 mg, 1.32 mmol) prepared in Example 398 and trifluoroacetate (1.0 mL, 13.05 mmol) were added at 0° C. to dichloromethane (6.0 mL). The reaction mixture was stirred at room temperature for 3 hours and then concentrated under reduced pressure to give 800.0 mg of the titled compound as a yellow liquid.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-50ff2256c6bd425eab5b58eb56776df1
Source dataset
uspto-grants-2016_06
Patent number
US09376420B2

Reaction notes

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