Phosphorus oxychloride → HCID 86666646, compound

HRID 2208117Notes

Reaction equation

HRID 2208117 reaction equation
O[C:2]1[C:3]2[NH:10][C:9]([CH3:11])=[C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]=2[N:5]=[CH:6][N:7]=1.O=P(Cl)(Cl)[Cl:19]>>[CH2:15]([O:14][C:12]([C:8]1[C:4]2[N:5]=[CH:6][N:7]=[C:2]([Cl:19])[C:3]=2[NH:10][C:9]=1[CH3:11])=[O:13])[CH3:16]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178469266HCID 178469266, compound

Product 1

HCID 86666646HCID 86666646, compound

Procedure

A reaction flask, equipped with a mechanic stirrer, a reflux condenser and a nitrogen bubbler is charged with POCl3 (1200 mL). Ethyl 4-hydroxy-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate from example A3 (207.19 g; 1.00 mol) is added in several portions. The carefully stirred suspension is heated to gentle reflux for five hours.

Workup

  1. customA reaction flask, equipped with a mechanic stirrer, a reflux condenser
  2. temperatureThe carefully stirred suspension is heated
  3. temperatureto gentle reflux for five hours

Sources & evidence

ORD record
ord-1faf89f6933f4c768cc1da2bb91d3b11
Source dataset
uspto-grants-2016_06
Patent number
US09376442B2

Reaction notes

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