Bromomethylcyclopropane → 2-Bromo-1-(cyclopropylmethoxy)-4-fluorobenzene

HRID 2208127Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].Br[CH2:11][CH:12]1[CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:11][CH:12]1[CH2:14][CH2:13]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 6054722-Bromo-4-fluorophenol

Product 1

HCID 435603962-Bromo-1-(cyclopropylmethoxy)-4-fluorobenzene

Procedure

Starting from commercially available 2-bromo-4-fluoro-phenol and commercially available bromomethyl-cyclopropane the title compound is obtained as colorless oil after distillation at 5×10−3 mbar.

Sources & evidence

ORD record: ord-aea5dd008f7346e6b5584335da62b021
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376442B2

Reaction notes

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