Bromomethylcyclopropane → 2-Bromo-1-(cyclopropylmethoxy)-4-(trifluoromethyl)benzene

HRID 2208131Notes

Reaction equation

HRID 2208131 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[OH:12].Br[CH2:14][CH:15]1[CH2:17][CH2:16]1>>[Br:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:5]=[CH:4][C:3]=1[O:12][CH2:14][CH:15]1[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 27611682-Bromo-4-(trifluoromethyl)phenol

Product 1

HCID 670329472-Bromo-1-(cyclopropylmethoxy)-4-(trifluoromethyl)benzene

Procedure

Starting from commercially available 2-bromo-4-trifluoromethyl-phenol and bromomethyl-cyclopropane the title compound is obtained as colorless oil after distillation at 5×10−3 mbar.

Sources & evidence

ORD record
ord-ecd95eb753eb407dadf32963376260ff
Source dataset
uspto-grants-2016_06
Patent number
US09376442B2

Reaction notes

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