反应详情

4-Piperidinemethanol (5.0 g, 43 mmol) was dissolved in dichloromethane (100 ml) and triethylamine (12 ml, 86 mmol) at 0° C. Benzylchloroformate (6.8 ml, 47.3 mmol) was added and the mixture was stirred for 20 h at room temperature then solvents were removed in vacuo. The residue was redissolved in EtOAc, washed with 1M KHSO4, water then brine, dried and concentrated in vacuo to yield the title compound (8.33 g, 77%).

1. customat 0° C
2. customsolvents were removed in vacuo
3. dissolutionThe residue was redissolved in EtOAc
4. washwashed with 1M KHSO4, water
5. dry with materialbrine, dried
6. concentrationconcentrated in vacuo