HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 45791623, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-[2-(4-methylphenyl)-2-oxoethyl]piperazine-1-carboxylate | HCID 56771152 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 45791623 | HCID 45791623 | 88% |
Reaction Steps
4-(2-Oxo-2-p-tolyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester from Example E36.1 (661 mg, 2.08 mmol) was dissolved in 4M HCl solution in dioxan (25 ml) at 0° C. and the mixture was stirred for 45 min at room temperature. Solvents were concentrated in vacuo and azeotroped with diethyl ether to yield the title compound (536 mg, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202858B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-5bcf64eaae894f5cb5c351ee06821705 |
| Source note | uspto-grants-2012_06 |