Hydrochloric Acid → HCID 45791623, compound

HRID 220836Notes

Reaction equation

HRID 220836 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[ClH:24].[N:11]1([CH2:14][C:15]([C:16]2[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=2)=[O:23])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 56771152Tert-butyl 4-[2-(4-methylphenyl)-2-oxoethyl]piperazine-1-carboxylate

Product 1

HCID 45791623HCID 45791623, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4-(2-Oxo-2-p-tolyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester from Example E36.1 (661 mg, 2.08 mmol) was dissolved in 4M HCl solution in dioxan (25 ml) at 0° C. and the mixture was stirred for 45 min at room temperature. Solvents were concentrated in vacuo and azeotroped with diethyl ether to yield the title compound (536 mg, 88%).

Workup

  1. concentrationSolvents were concentrated in vacuo
  2. customazeotroped with diethyl ether

Sources & evidence

ORD record
ord-5bcf64eaae894f5cb5c351ee06821705
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

Loading…