Triethylamine → 5,6-difluorobenzo[c][1,2,5]thiadiazole

Temperature

0 °C

A dry 1000 mL round bottom flask, equipped with a condenser, was purged with nitrogen and charged with 4,5-difluorobenzene-1,2-diamine (10 g, 0.069 mol), 400 mL of anhydrous methylene chloride (CH2Cl2), and triethylamine (38.7 mL, 0.28 mol). The reaction flask was cooled to 0° C. and thionyl chloride (30.2 mL, 0.41 mol) was added drop-wise. The ice bath was removed and the mixture was heated to reflux for 1 hour. Completion of reaction was monitored by GC-MS. As the reaction was completed, the mixture was concentrated down, quenched with cold water, and extracted with CH2Cl2 (3×300 mL). The organic phase was dried over anhydrous MgSO4, filtered, and concentrated down. The final product was purified using column chromatography on silica gel with hexanes/ethyl acetate (80:20) gradient to yield white crystalline solid (6.3 g, 53%). Spectral data: 1H NMR (300 MHz, CDCl3): δH 7.75 (t, 2H).

1. customA dry 1000 mL round bottom flask, equipped with a condenser
2. customwas purged with nitrogen
3. customThe ice bath was removed
4. temperaturethe mixture was heated
5. temperatureto reflux for 1 hour
6. customCompletion of reaction
7. concentrationthe mixture was concentrated down
8. customquenched with cold water
9. extractionextracted with CH2Cl2 (3×300 mL)
10. dry with materialThe organic phase was dried over anhydrous MgSO4
11. filtrationfiltered
12. concentrationconcentrated down
13. customThe final product was purified

ORD record

ord-88614895824b480cb6fb583483d2834a

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09376529B2