Phosphate → L-tert-Leucine

HRID 2208638Notes

Reaction equation

[CH3:1][C:2]([CH3:9])([CH3:8])[C:3](=O)[C:4]([O-:6])=[O:5].[NH2:10][C@H](C(O)=O)CC.C(N)(C)C.P([O-])([O-])([O-])=O>>[NH2:10][C@H:3]([C:4]([OH:6])=[O:5])[C:2]([CH3:9])([CH3:8])[CH3:1]

Participants

Reactant 4

HCID 1061Phosphate

HCID 6363Isopropylamine

HCID 80283(-)-2-Aminobutyric acid

HCID 21320258HCID 21320258, compound

Product 1

HCID 164608L-tert-Leucine

Procedure

L-tert-Leucine was produced with a conversion of 97% by conducting reactions using 50 mL of a mixture of 0.3 M trimethylpyruvate, 20 mM L-homoalanine, 0.45 M isopropylamine, 0.5 mM PLP, 50 mM phosphate pH 8, 35 U/mL BCTA and 30 U/mL OATA. 1.365 g of pure L-tert-leucine was obtained through purification based on solubility.

Sources & evidence

ORD record: ord-765ae7d06f464a2ab00b6f39812786af
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376694B2

Reaction notes

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