反应详情

温度

50 °C

To a stirred solution of methyl 3-[ethyl(1-methylpiperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate (700 mg, 1.95 mmol) in methanol (15 mL) was added aq. NaOH (5M, 590 ul, 2.93 mmol). The reaction mixture was stirred at 50° C. for 3 hours. After cooling to 23° C., HCl (2 M) was added to the mixture. The mixture was acidified to pH=5 and was concentrated in vacuo to give the titled compound as crude products (1.26 g).

1. temperatureAfter cooling to 23° C.
2. concentrationwas concentrated in vacuo