反应详情

温度

50 °C

To a stirred solution of methyl 5-chloro-3-[ethyl(1-methylpiperidin-4-yl)amino]-2-methylbenzoate (1.06 g, 3.26 mmol) in methanol (10 mL) was added aq. NaOH (5 M, 780 ul, 3.92 mmol). The reaction mixture was stirred at 50° C. for 18 hours. After cooling to 23° C., HCl (2 M, 2 mL)) was added to the mixture and the mixture was acidified to pH=5 and was concentrated in vacuo to give the titled compound as crude products (1.80 g).

1. temperatureAfter cooling to 23° C.
2. concentrationwas concentrated in vacuo