反应详情

温度

60 °C

To stirred solution of 2-methyl-3-nitro-5-(trifluoromethyl)benzoic acid (1 g, 4.01 mmol) in DMF (3 mL) was added sodium carbonate (0.63 g, 6.02 mmol) and methyl iodide (1.14 g, 8.03 mmol). The resulting mixture was heated at 60° C. for 4 h. On completion, water was added to the reaction, and the product extracted using DCM. Combined organic layers were dried, concentrated under reduced pressure and purified by column chromatography over silica to give methyl 2-methyl-3-nitro-5-(trifluoromethyl)benzoate (1 g, 95.2%).

1. extractionthe product extracted
2. customCombined organic layers were dried
3. concentrationconcentrated under reduced pressure
4. custompurified by column chromatography over silica