反应详情

To the stirred solution of NaOH (60 g) in water (1152 ml) was added bromine (36 ml) dropwise at 0° C. and stirred the reaction mixture for 45 min. at same temperature. 2,4-dimethylbenzoic acid (12 g, 79.9 mmol) was added in above reaction mixture at 0° C. portion wise and stirred the reaction at room temperature for 3 h. After completion of reaction of reaction (TLC) reaction mixture was acidified using conc. HCl, solid was filtered through Buchner funnel and wash with water and dried to afford the desired compound (12 g, 65%) which was used without further purification.

1. stirringstirred
2. customthe reaction at room temperature for 3 h
3. customAfter completion of reaction of reaction (TLC) reaction mixture
4. filtrationwas filtered through Buchner funnel
5. washwash with water
6. customdried