Allyl bromide → HCID 86719546, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 5-chloro-3-(cyclopentylamino)-2-methylbenzoate (1.2 g, 4.46 mmol) was dissolved in DMF (12 mL) and cooled to 0° C. NaH (0.21 g, 8.92 mmol) was added after 10 minutes and allyl bromide (1.07 g, 8.9 mmol) was added. The reaction mixture was stirred at room temperature for 4 h and then heated at 80 0° C. for 18 h. The reaction was quenched with ice water and extracted with ethyl acetate. Combined organic layers were dried, concentrated giving crude methyl 3-(allyl(cyclopentyl)amino)-5-chloro-2-methylbenzoate (0.4 g, 29.4%).

Provenance & Evidence