Acetic Acid → HCID 70872494, compound

Participants

Reaction Steps

To a stirred solution of methyl 3-amino-5-bromo-2-methylbenzoate (3 g, 13.3 mmol) and cyclopentanone (5.6 g, 66 mmol) in methanol (30 mL), acetic acid (1.59 g, 26.6 mmol) was added and reaction stirred at room temperature for 3 h. Then sodium cyanoborohydride (2.08 g, 29.4 mmol) was added and reaction stirred overnight. On completion, solvent was removed under reduced pressure and crude material was used without further purification.

Provenance & Evidence