Acetic Acid → HCID 70872494, compound

HRID 2208760Notes

Reaction equation

HRID 2208760 reaction equation
[NH2:1][C:2]1[C:3]([CH3:13])=[C:4]([CH:9]=[C:10]([Br:12])[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:14]1(=O)[CH2:18][CH2:17][CH2:16][CH2:15]1.C(O)(=O)C.C([BH3-])#N.[Na+]>CO>[Br:12][C:10]1[CH:11]=[C:2]([NH:1][CH:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:3]([CH3:13])=[C:4]([CH:9]=1)[C:5]([O:7][CH3:8])=[O:6]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 8452CyclopentanoneHCID 5003444Sodium cyanoborohydrideHCID 24729181Methyl 3-Amino-5-bromo-2-methylbenzoate

Product 1

HCID 70872494HCID 70872494, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of methyl 3-amino-5-bromo-2-methylbenzoate (3 g, 13.3 mmol) and cyclopentanone (5.6 g, 66 mmol) in methanol (30 mL), acetic acid (1.59 g, 26.6 mmol) was added and reaction stirred at room temperature for 3 h. Then sodium cyanoborohydride (2.08 g, 29.4 mmol) was added and reaction stirred overnight. On completion, solvent was removed under reduced pressure and crude material was used without further purification.

Workup

  1. customreaction
  2. customreaction
  3. stirringstirred overnight
  4. customOn completion, solvent was removed under reduced pressure and crude material
  5. customwas used without further purification

Sources & evidence

ORD record
ord-64b580cb76d24335a75b635e63f0db3f
Source dataset
uspto-grants-2016_06
Patent number
US09376422B2

Reaction notes

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