Acetyl chloride → HCID 136128384, compound

HRID 220877Notes

Reaction equation

HRID 220877 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].Cl.Cl.[CH3:7][N:8]1[C:17]2[NH:16][C:15]3[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=3[N:13]([C:22]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][CH2:33][N:34]4[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]4)=[C:26]([CH3:40])[CH:25]=3)=[O:23])[CH2:12][C:11]=2[CH:10]=[N:9]1>ClCCl.C(N(CC)CC)C>[CH3:40][C:26]1[CH:25]=[C:24]([C:22]([N:13]2[CH2:12][C:11]3[CH:10]=[N:9][N:8]([CH3:7])[C:17]=3[NH:16][C:15]3[CH:18]=[CH:19][CH:20]=[CH:21][C:14]2=3)=[O:23])[CH:29]=[CH:28][C:27]=1[O:30][CH2:31][CH2:32][CH2:33][N:34]1[CH2:39][CH2:38][N:37]([C:1](=[O:3])[CH3:2])[CH2:36][CH2:35]1

Participants

5

Reactant 2

HCID 6367Acetyl chlorideHCID 136346640HCID 136346640, compound

Product 1

HCID 136128384HCID 136128384, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of acetyl chloride (0.39 mg, 0.005 mmol) in dichloromethane (0.05 ml) was added to a solution of (3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulen-9-yl)-[3-methyl-4-(3-piperazin-1-yl-propoxy)-phenyl]-methanone dihydrochloride (Compound number 408) (2.67 mg, 0.005 mmol) in dichloromethane (0.05 ml) and triethylamine (0.0035 ml). The mixture was stirred at room temperature for 1 h then solvents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=503.2

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-367b4b3bd716431c85802f75fa0b2711
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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