Methanesulfonyl chloride → HCID 136128344, compound

HRID 220878Notes

Reaction equation

HRID 220878 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].Cl.Cl.[CH3:8][N:9]1[C:18]2[NH:17][C:16]3[CH:19]=[CH:20][CH:21]=[CH:22][C:15]=3[N:14]([C:23]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][CH2:34][N:35]4[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]4)=[C:27]([CH3:41])[CH:26]=3)=[O:24])[CH2:13][C:12]=2[CH:11]=[N:10]1>ClCCl.C(N(CC)CC)C>[CH3:1][S:2]([N:38]1[CH2:37][CH2:36][N:35]([CH2:34][CH2:33][CH2:32][O:31][C:28]2[CH:29]=[CH:30][C:25]([C:23]([N:14]3[CH2:13][C:12]4[CH:11]=[N:10][N:9]([CH3:8])[C:18]=4[NH:17][C:16]4[CH:19]=[CH:20][CH:21]=[CH:22][C:15]3=4)=[O:24])=[CH:26][C:27]=2[CH3:41])[CH2:40][CH2:39]1)(=[O:4])=[O:3]

Participants

5

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 136346640HCID 136346640, compound

Product 1

HCID 136128344HCID 136128344, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of methanesulfonyl chloride (0.57 mg, 0.005 mmol) in dichloromethane (0.05 ml) was added to a solution of (3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulen-9-yl)-[3-methyl-4-(3-piperazin-1-yl-propoxy)-phenyl]-methanone dihydrochloride (Compound number 408) (2.67 mg, 0.005 mmol) in dichloromethane (0.05 ml) and triethylamine (0.0035 ml). The mixture was stirred at room temperature for 1 h then solvents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=539.2

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-5986c1bcf7424989b4fef2d1a2f55df4
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

Loading…