4-(Methylamino)tetrahydro-2H-pyran → Methyl 3,6-dichloro-4-[methyl(oxan-4-yl)amino]pyridine-2-carboxylate
Reaction equation
[Cl:1][C:2]1[C:3]([C:10]([O:12][CH3:13])=[O:11])=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1Cl.[CH3:14][NH:15][CH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>CN(C=O)C>[Cl:1][C:2]1[C:3]([C:10]([O:12][CH3:13])=[O:11])=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1[N:15]([CH3:14])[CH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1Participants
Conditions
- Temperature
- 100 °C
Procedure
To a stirred solution of methyl 3,4,6-trichloropyridine-2-carboxylate (600 mg, 2.50 mmol) in DMF (12 ml) was added TEA (696 μl, 4.99 mmol) followed by N-methyloxan-4-amine (287 mg, 2.50 mmol) and the reaction mixture was heated at 100° C. for 20 h. The reaction mixture was then cooled to room temperature and poured onto water (100 ml), followed by extraction of the product into EtOAc (3×100 ml), washing of the combined organics with brine (50 ml), drying with Na2SO4 and evaporation. The crude product was then purified over a 10 g silica Isolute column eluting with a gradient of 0% to 60% EtOAc in heptane to afford the title compound as a white solid (114 mg, 14%). LC-MS 100%, 1.91 min (3.5 minute LC-MS method), m/z=319.3/320.9, 1H NMR (500 MHz, Chloroform-d) δ 6.87 (s, 1H), 4.15-4.00 (m, 2H), 3.98 (s, 3H), 3.93-3.71 (m, 1H), 3.54-3.24 (m, 2H), 2.82 (s, 3H), 1.94 (dd, J=12.1, 4.7 Hz, 2H), 1.70 (d, J=10.2 Hz, 2H). (br. s., 4H) 1.48 (s, 9H)
Workup
- temperatureThe reaction mixture was then cooled to room temperature
- additionpoured onto water (100 ml)
- extractionfollowed by extraction of the product into EtOAc (3×100 ml)
- washwashing of the combined organics with brine (50 ml)
- dry with materialdrying with Na2SO4 and evaporation
- customThe crude product was then purified over a 10 g silica Isolute column
- washeluting with a gradient of 0% to 60% EtOAc in heptane
Sources & evidence
- ORD record
- ord-696de4be89744608ad2f2e1945260b24
- Source dataset
- uspto-grants-2016_06
- Patent number
- US09376422B2
Reaction notes
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