Diisopropylethylamine → HCID 70873752, compound

HRID 2208854Notes

Reaction equation

HRID 2208854 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:13]([CH2:20][CH3:21])[CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[NH2:64][CH2:65][C:66]1[C:67](=[O:74])[NH:68][C:69]([CH3:73])=[CH:70][C:71]=1[CH3:72]>CN(C=O)C.O>[Cl:1][C:2]1[CH:3]=[C:4]([N:13]([CH2:20][CH3:21])[CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([NH:64][CH2:65][C:66]1[C:67](=[O:74])[NH:68][C:69]([CH3:73])=[CH:70][C:71]=1[CH3:72])=[O:9]

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 2724699PyBOPHCID 70638443-(Aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-oneHCID 70873687HCID 70873687, compound

Product 1

HCID 70873752HCID 70873752, compoundYield 67%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a solution of 5-chloro-3-[ethyl(oxan-4-yl)amino]-2-methoxybenzoic acid (111 mg, 0.35 mmol) in DMF (3 ml) at room temperature under nitrogen was added PyBOP (220 mg, 0.42 mmol) followed by N-ethyl-N-(propan-2-yl)propan-2-amine (92 μl, 0.53 mmol) and 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one (89%, 66 mg, 0.39 mmol). After stirring for 1.5 hours at room temperature no starting material was observed by LCMS. Deionized water (20 ml) was added to the reaction mixture and the resultant precipitate was collected by filtration. The solid was washed with deionized water (3×5 ml) before being air dried. The solid was further purified by FCC (5 g silica, Isolute cartridge, gradient of eluents; 100% DCM to 97:3 DCM:MeOH). The sample was dried in a vacuum oven for 18 hours to give 105 mg (64%) the title compound as an off-white solid. LC-MS 98%, m/z=449.5/452.1, 1H NMR (500 MHz, Chloroform-d) δ ppm 11.47 (s, 1H), 8.79 (t, J=5.8 Hz, 1H), 7.73 (d, J=2.6 Hz, 1H), 7.05 (d, J=2.6 Hz, 1H), 5.92 (s, 1H), 4.55 (d, J=6.0 Hz, 2H), 3.98 (dd, J=11.3, 3.8 Hz, 2H), 3.78 (s, 3H), 3.35 (t, J=11.6 Hz, 3H), 3.12 (q, J=7.0 Hz, 2H), 2.42 (s, 3H), 2.28 (s, 3H), 1.92-1.61 (m, 4H), 0.94 (t, J=7.0 Hz, 3H).

Workup

  1. filtrationthe resultant precipitate was collected by filtration
  2. washThe solid was washed with deionized water (3×5 ml)
  3. customdried
  4. customThe solid was further purified by FCC (5 g silica, Isolute cartridge, gradient of eluents; 100% DCM to 97:3 DCM:MeOH)
  5. customThe sample was dried in a vacuum oven for 18 hours

Sources & evidence

ORD record
ord-3bc072aa35324da4a3c8f129a998116b
Source dataset
uspto-grants-2016_06
Patent number
US09376422B2

Reaction notes

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