Methanesulfonyl chloride → HCID 136128342, compound

HRID 220886Notes

Reaction equation

HRID 220886 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][N:7]1[C:16]2[NH:15][C:14]3[CH:17]=[C:18]([CH3:21])[CH:19]=[CH:20][C:13]=3[N:12]([C:22]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32]([N:34]4[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]4)=[O:33])=[C:26]([CH3:40])[CH:25]=3)=[O:23])[CH2:11][C:10]=2[CH:9]=[N:8]1>ClCCl.C(N(CC)CC)C>[CH3:6][N:7]1[C:16]2[NH:15][C:14]3[CH:17]=[C:18]([CH3:21])[CH:19]=[CH:20][C:13]=3[N:12]([C:22]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32]([N:34]4[CH2:39][CH2:38][N:37]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:36][CH2:35]4)=[O:33])=[C:26]([CH3:40])[CH:25]=3)=[O:23])[CH2:11][C:10]=2[CH:9]=[N:8]1

Participants

5

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 136128407HCID 136128407, compound

Product 1

HCID 136128342HCID 136128342, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of methanesulfonyl chloride (0.57 mg, 0.005 mmol) in dichloromethane (0.05 ml) was added to a solution of 3-[4-(3,6-dimethyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-2-methyl-phenyl]-1-piperazin-1-yl-propan-1-one (2.36 mg, 0.005 mmol) in dichloromethane (0.05 ml) and triethylamine (0.0035 ml). The mixture was stirred at room temperature for 20 h then solvents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=551.3

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-0622bef2d8f046baaf9daf561ce80dbd
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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