Water → Methyl 5-chloro-2-methyl-3-nitrobenzoate

HRID 2208897Notes

Reaction equation

HRID 2208897 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[C:15](=O)([O-])[O-].[Na+].[Na+].CI.O>CN(C=O)C.C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:15])=[O:8]

Participants

7

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 10340Sodium CarbonateHCID 230097625-Chloro-2-methyl-3-nitrobenzoic acid

Product 1

HCID 53399191Methyl 5-chloro-2-methyl-3-nitrobenzoate

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
60 °C

Procedure

To a stirred solution of 5-chloro-2-methyl-3-nitrobenzoic acid (6.75 g, 31.3 mmol) in DMF (33 mL), sodium carbonate (13.2 g, 125 mmol) and methyl iodide (17.8 g, 125 mmol) were added. The mixture was heated at 60° C. for 4 h. On completion, water was added to the reaction mass and extraction was carried out using DCM. The combined organic layers were dried, concentrated under reduced pressure and purified by column chromatography over silica gel giving the title compound (6.0 g, 83%).

Workup

  1. customThe combined organic layers were dried
  2. concentrationconcentrated under reduced pressure
  3. custompurified by column chromatography over silica gel giving the title compound (6.0 g, 83%)

Sources & evidence

ORD record
ord-70d265f1ac544f73a4256f0721343613
Source dataset
uspto-grants-2016_06
Patent number
US09376422B2

Reaction notes

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