反应详情

To a solution of 2-bromo-5-fluoro-4-nitropyridine 1-oxide (3000 mg, 12.66 mmol) in THF (10 mL) was added cyclopropylamine (868 mg, 15.1 mmol). Solution was stirred at room temperature for 1 h. Mixture was partitioned between EtOAc and saturated aqueous NaHCO3. Organic layer was washed with brine and dried over MgSO4 to provide 2-bromo-5-(cyclopropylamino)-4-nitropyridine 1-oxide 2.67. Residue was used for next step without further purification. LC/MS found for C8H8BrN3O3 as (M+H)+ 275.9.

1. customMixture was partitioned between EtOAc and saturated aqueous NaHCO3
2. washOrganic layer was washed with brine
3. dry with materialdried over MgSO4