Ammonium Hydroxide → HCID 117843538, compound

N-cyclopropyl-2-methoxy-6-nitroaniline (1.05 g, 5.04 mmol) was dissolved in MeOH (25 mL). Bromine (0.27 mL, 5.2 mmol) was added dropwise over 1 min, and the resulting mixture was stirred 1 h. Additional bromine (0.05 mL, 0.98 mmol) was then added and the resulting mixture was stirred for an additional 30 min. The mixture was then diluted with DCM (75 mL) and H2O (50 mL), and the aqueous phase was basified with saturated aqueous NH4OH (2 mL). The phases were separated, and the aqueous phase was extracted with DCM (30 mL). The combined organic phase was dried over Na2SO4, filtered, and concentrated. The resulting residue was purified by silica gel chromatography (0-25% EtOAc in hexanes) to afford 4-bromo-N-cyclopropyl-2-methoxy-6-nitroaniline. LCMS-ESI+ (m/z): [M+H]+ calcd for C10H12BrN2O3: 287.0; found: 286.9.

1. stirringthe resulting mixture was stirred for an additional 30 min
2. customThe phases were separated
3. extractionthe aqueous phase was extracted with DCM (30 mL)
4. dry with materialThe combined organic phase was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. customThe resulting residue was purified by silica gel chromatography (0-25% EtOAc in hexanes)

ORD record

ord-4fa53ce521e94444a83229b368260894

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09376441B2