Hydrochloric Acid → HCID 67286922, compound

HRID 220904Notes

Reaction equation

HRID 220904 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([N:26]3[CH2:35][CH2:34][C:33]4[N:32]=[C:31]([CH3:36])[N:30]([CH2:37][C:38]5[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=5)[C:29]=4[C:28]4[CH:44]=[CH:45][CH:46]=[CH:47][C:27]3=4)=[O:25])=[CH:20][C:19]=2[CH3:48])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:49]>CO.O1CCOCC1>[ClH:49].[ClH:49].[CH2:37]([N:30]1[C:29]2[C:28]3[CH:44]=[CH:45][CH:46]=[CH:47][C:27]=3[N:26]([C:24]([C:21]3[CH:22]=[CH:23][C:18]([O:17][CH2:16][CH2:15][CH2:14][N:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)=[C:19]([CH3:48])[CH:20]=3)=[O:25])[CH2:35][CH2:34][C:33]=2[N:32]=[C:31]1[CH3:36])[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57555265HCID 57555265, compound

Product 1

HCID 67286922HCID 67286922, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

4-{3-[4-(1-Benzyl-2-methyl-4,5-dihydro-1H-1,3,6-triaza-benzo[e]azulene-6-carbonyl)-2-methyl-phenoxy]-propyl}-piperazine-1-carboxylic acid tert-butyl ester from Example E70.1 (230 mg, 0.35 mmol) was dissolved in methanol (5 ml) and 4M HCl in dioxan (2 ml) was added. The mixture was stirred for 2 h at room temperature then concentrated in vacuo and triturated with diethyl ether to yield the title compound (215 mg, 98%).

Workup

  1. concentrationthen concentrated in vacuo
  2. customtriturated with diethyl ether

Sources & evidence

ORD record
ord-06d7dae7690a4b6488b0329e9bb91d36
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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