Trifluoroacetic acid → HCID 117843830, compound

HRID 2209095Notes

Reaction equation

HRID 2209095 reaction equation
[CH:1]1([N:4]2[C:8]3[C:9]([O:32][C@@H:33]([C@H:35]4[CH2:39][NH:38][C:37](=[O:40])[CH2:36]4)[CH3:34])=[N:10][C:11]([C:13]4[CH:18]=[CH:17][N:16]=[C:15]([C:19]5[CH:20]=[N:21][N:22](COCC[Si](C)(C)C)[CH:23]=5)[CH:14]=4)=[CH:12][C:7]=3[N:6]=[CH:5]2)[CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>>[NH:21]1[CH:20]=[C:19]([C:15]2[CH:14]=[C:13]([C:11]3[N:10]=[C:9]([O:32][C@@H:33]([C@H:35]4[CH2:39][NH:38][C:37](=[O:40])[CH2:36]4)[CH3:34])[C:8]4[N:4]([CH:1]5[CH2:3][CH2:2]5)[CH:5]=[N:6][C:7]=4[CH:12]=3)[CH:18]=[CH:17][N:16]=2)[CH:23]=[N:22]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 123366585HCID 123366585, compound

Product 1

HCID 117843830HCID 117843830, compound

Procedure

the crude material (R)-4-((R)-1-((3-cyclopropyl-6-(2-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)pyridin-4-yl)-3H-imidazo[4,5-c]pyridin-4-yl)oxy)ethyl)pyrrolidin-2-one: was treated with TFA at rt for 30 minute. LC-MS showed reaction was complete. Reaction mixture was stripped off and purified by HPLC to afford title compound.

Workup

  1. customreaction
  2. customReaction mixture
  3. custompurified by HPLC

Sources & evidence

ORD record
ord-ac2350c32d1d4336baea5ec0affabc33
Source dataset
uspto-grants-2016_06
Patent number
US09376441B2

Reaction notes

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