6-Oxa-3-azabicyclo[3.1.1]heptane → HCID 84804635, compound

HRID 2209109Notes

Reaction equation

HRID 2209109 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH:12]3[CH2:14][CH:10](N3C(OC(C)(C)C)=O)[CH2:9]2)=[CH:4][CH:3]=1.C12CC([O:27]1)CNC2>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH:12]3[CH2:14][CH:10]([O:27]3)[CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 179658576-Oxa-3-azabicyclo[3.1.1]heptaneHCID 117843577HCID 117843577, compound

Product 1

HCID 84804635HCID 84804635, compoundYield 61%

Procedure

Prepared by the procedure, previously described for the synthesis of tert-butyl 3-(4-bromophenyl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate, using instead 6-oxa-3-azabicyclo[3.1.1]heptane as a starting material to afford 570.0 mg (61%) of 3-(4-bromophenyl)-6-oxa-3-azabicyclo[3.1.1]heptane.

Workup

  1. customPrepared by the procedure

Sources & evidence

ORD record
ord-e11d3272f5b94e3db9d646e06c792f01
Source dataset
uspto-grants-2016_06
Patent number
US09376441B2

Reaction notes

Loading…