HCID 117844082, compound → 2-(3-iodo-1H-pyrazol-1-yl)-2-methylpropanoic acid

HRID 2209268Notes

Reaction equation

HRID 2209268 reaction equation
[I:1][C:2]1[CH:6]=[CH:5][N:4]([C:7]([CH3:16])([CH3:15])[C:8]([O:10]C(C)(C)C)=[O:9])[N:3]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[I:1][C:2]1[CH:6]=[CH:5][N:4]([C:7]([CH3:16])([CH3:15])[C:8]([OH:10])=[O:9])[N:3]=1

Participants

4

Reactant 1

HCID 117844082HCID 117844082, compound

Product 1

HCID 1178438732-(3-iodo-1H-pyrazol-1-yl)-2-methylpropanoic acid

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

tert-butyl 2-(3-iodo-1H-pyrazol-1-yl)-2-methylpropanoate 7.03 (530 mg, 1.58 mmol) was dissolved in DCM (7 mL) and TFA (7 mL). The reaction was stirred at r.t. for 18 h and was concentrated in vacuo to afford crude 2-(3-iodo-1H-pyrazol-1-yl)-2-methylpropanoic acid 7.04 that was used without further purification. LCMS-ESI+ (m/z): [M+H]+ calcd for C7H10IN2O2: 280.98; found: 280.91.

Workup

  1. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-ed3ef24f73014ac1ad31b21472419cec
Source dataset
uspto-grants-2016_06
Patent number
US09376441B2

Reaction notes

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