1-Chloro-4-(3,4-difluorophenyl)-1-silacyclohexane → HCID 178448136, compound

Participants

Reaction Steps

4.1 g (20 mmol) of 4-n-propylcyclohexyl bromide was dropped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of tetrahydrofuran (THF) to obtain Grignard reagent. This solution was then dropped into a 50 ml THF solution of 4.9 g (20 mmol) of 4-(4-chloro-4-silacyclohexyl)-1,2-difluorobenzene to obtain 4-(4-(trans-4-n-propylcyclohexyl)-4-silacyclohexyl)-1, 2-difluorobenzene.

Provenance & Evidence