1-Chloro-4-(3,4-difluorophenyl)-1-silacyclohexane → HCID 178448136, compound

HRID 2209366Notes

Reaction equation

HRID 2209366 reaction equation
Cl[SiH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=2)[CH2:4][CH2:3]1>O1CCCC1>[CH2:5]([C@H:8]1[CH2:13][CH2:12][C@H:11]([SiH:2]2[CH2:7][CH2:6][CH:5]([C:8]3[CH:13]=[CH:12][C:11]([F:14])=[C:10]([F:15])[CH:9]=3)[CH2:4][CH2:3]2)[CH2:10][CH2:9]1)[CH2:4][CH3:3]

Participants

3

Reactant 1

HCID 1317191281-Chloro-4-(3,4-difluorophenyl)-1-silacyclohexane

Product 1

HCID 178448136HCID 178448136, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4.1 g (20 mmol) of 4-n-propylcyclohexyl bromide was dropped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of tetrahydrofuran (THF) to obtain Grignard reagent. This solution was then dropped into a 50 ml THF solution of 4.9 g (20 mmol) of 4-(4-chloro-4-silacyclohexyl)-1,2-difluorobenzene to obtain 4-(4-(trans-4-n-propylcyclohexyl)-4-silacyclohexyl)-1, 2-difluorobenzene.

Sources & evidence

ORD record
ord-bf596d5404cb4677a92eb079c408edbe
Source dataset
uspto-grants-1995_10
Patent number
US05454977

Reaction notes

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