Propionyl chloride → HCID 136128394, compound

HRID 220949Notes

Reaction equation

HRID 220949 reaction equation
[C:1](Cl)(=[O:4])[CH2:2][CH3:3].Cl.[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[N:20]([C:21]([C:23]3[CH:40]=[CH:39][C:26]([CH2:27][NH:28][C:29](=[O:38])[CH2:30][CH2:31][CH:32]4[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]4)=[CH:25][C:24]=3[CH3:41])=[O:22])[CH2:19][C:18]3[CH:17]=[N:16][N:15]([CH3:42])[C:14]=3[NH:13][C:12]=2[CH:43]=1>ClCCl.C(N(CC)CC)C>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[N:20]([C:21]([C:23]3[CH:40]=[CH:39][C:26]([CH2:27][NH:28][C:29](=[O:38])[CH2:30][CH2:31][CH:32]4[CH2:37][CH2:36][N:35]([C:1](=[O:4])[CH2:2][CH3:3])[CH2:34][CH2:33]4)=[CH:25][C:24]=3[CH3:41])=[O:22])[CH2:19][C:18]3[CH:17]=[N:16][N:15]([CH3:42])[C:14]=3[NH:13][C:12]=2[CH:43]=1

Participants

5

Reactant 2

HCID 62324Propionyl chlorideHCID 136346647HCID 136346647, compound

Product 1

HCID 136128394HCID 136128394, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolvent2×HCID 8471TriethylamineSolvent

Procedure

A solution of propionyl chloride (0.46 mg, 0.005 mmol) in dichloromethane (0.05 ml) was added to a solution of N-[4-(6-chloro-3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-3-methyl-benzyl]-3-piperidin-4-yl-propionamide hydrochloride (Compound number 1108) (2.97 mg, 0.005 mmol) in dichloromethane (0.05 ml) and triethylamine (0.0035 ml). The mixture was stirred at room temperature for 1 h then solvents were removed in vacuo to yield the title compound. (ESI)+: [M+H]+=577.4

Workup

  1. customsolvents were removed in vacuo

Sources & evidence

ORD record
ord-a79d6589e7074dd2963a5f9a90344bb9
Source dataset
uspto-grants-2012_06
Patent number
US08202858B2

Reaction notes

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