p-Toluenesulfonic acid monohydrate → 2-Trifluoromethyl-4-(3-cyanophenyl)-4, 6,7,8-tetrahydro-5(1H)-quinolone

HRID 2209541Notes

Reaction equation

HRID 2209541 reaction equation
C([CH:4]1[CH:13]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=2)[C:12]2[C:11](=[O:22])[CH2:10][CH2:9][CH2:8][C:7]=2[NH:6][C:5]1([C:24]([F:27])([F:26])[F:25])O)(O)=O.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[F:27][C:24]([F:25])([F:26])[C:5]1[NH:6][C:7]2[CH2:8][CH2:9][CH2:10][C:11](=[O:22])[C:12]=2[CH:13]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=2)[CH:4]=1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 154912663-carboxy-2-trifluoromethyl-2-hydroxy-4-(3-cyanophenyl)-4,6,7,8-tetrahydro-5 (1H)-quinolone

Product 1

HCID 111629272-Trifluoromethyl-4-(3-cyanophenyl)-4, 6,7,8-tetrahydro-5(1H)-quinoloneYield 55.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of 3-carboxy-2-trifluoromethyl-2-hydroxy-4-(3-cyanophenyl)- 4,6,7,8-tetrahydro-5(1H)-quinolone (2.25 g) in toluene (100 ml) was treated with p-toluene sulfonic acid monohydrate (0.33 g). The mixture was vigorously refluxed under Dean-Stark conditions for 1.5 hours and then partitioned between water and ethyl acetate. The organic portion was washed (water and brine) and evaporated. The residue was purified by chromatography (hexane/ethyl acetate, 1:1) to yield the title compound (1.04 g) as a white solid; m.p. 182°-183° C.; NMR: 1.80-2.00(m,2, CH2), 2.13-2.30(m,2,CH2), 2.50-2.67(m,2,CH2), 4.68(d,1, CH, J=5.2), 5.61(d,1, CH, J=5.3), 7.51(m,2, Ar), 7.60(s, 1, Ar), 7.64(m,1, Ar), 9.42(s, 1, NH); MS: m/z=318(M); Analysis for C17H13F3N2O: Calculated C, 64.15; H, 4.12; N, 8.80; Found: C, 64.15; H, 4.10; N, 8.63.

Workup

  1. temperatureThe mixture was vigorously refluxed under Dean-Stark conditions for 1.5 hours
  2. custompartitioned between water and ethyl acetate
  3. washThe organic portion was washed (water and brine)
  4. customevaporated
  5. customThe residue was purified by chromatography (hexane/ethyl acetate, 1:1)

Sources & evidence

ORD record
ord-eab134598b90402e8a4abfeedffe6a50
Source dataset
uspto-grants-1995_10
Patent number
US05455253

Reaction notes

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