Methanol → 1-(9,10-Dihydro-9,10-methanoanthracen-9-ylmethyl)piperidin-4-ol

HRID 2209600Notes

Reaction equation

HRID 2209600 reaction equation
[CH:1]1[C:14]2[C:13]3([C:16]([N:18]4[CH2:23][CH2:22][CH:21]([OH:24])[CH2:20][CH2:19]4)=O)[CH2:15][CH:6]([C:7]4[C:12]3=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:5]=2[CH:4]=[CH:3][CH:2]=1.CO>C(Cl)(Cl)Cl>[CH:11]1[C:12]2[C:13]3([CH2:16][N:18]4[CH2:23][CH2:22][CH:21]([OH:24])[CH2:20][CH2:19]4)[CH2:15][CH:6]([C:5]4[C:14]3=[CH:1][CH:2]=[CH:3][CH:4]=4)[C:7]=2[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 21480612HCID 21480612, compound

Product 1

HCID 214806171-(9,10-Dihydro-9,10-methanoanthracen-9-ylmethyl)piperidin-4-olYield 88%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using a procedure similar to that described in Example 82b except starting with 1-(9,10-dihydro-9,10-methanoanthracen-9-ylcarbonyl)piperidin-4-ol (described in Example 83b), the title compound was formed in 88% yield as a white solid TLC analysis (Rf 0.59, 10% methanol in chloroform). MS (CI, CH4) m/z 306 (M+1,100), 334 (M+29,14), 288 (62), 114(8)

Sources & evidence

ORD record
ord-c9e6e629b82d4b94ad1d7c24d49b09d0
Source dataset
uspto-grants-1995_10
Patent number
US05455246

Reaction notes

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