反应详情

温度

25 °C

Serine methyl ester hydrochloride [HOCH2CH(NH2)CO2CH3.HCl] (18.7 g; 0.120 mol) and imidazole (30 g; 0.44 mol) are dissolved in DMF (100 ml) and cooled to 0° C. t-Butyldimethylsilyl chloride (19.5 g; 0.13 mol) is added and the reaction allowed to stir 15 hours at 25° C. The reaction is then diluted with ether (2 L), washed with water (4×500 ml), dried (MgSO4) and concentrated to yield t-butyldimethylsilyloxyserine methyl ester as an oil which is used directly in Step B.

1. additionis added
2. washwashed with water (4×500 ml)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated