反应详情

温度

170 °C

A mixture of 2-fluoro-4-methoxy-benzonitrile (500 mg, 0.246 mmol) and pyridine hydrochloride (2.0 g, 17.2 mmol) is heated at 170° C. for 5 hours. The reaction is partitioned between ethyl acetate and 1N hydrochloric acid. The organic phase is washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford 2-fluoro-4-hydroxy-benzonitrile.

1. customThe reaction is partitioned between ethyl acetate and 1N hydrochloric acid
2. washThe organic phase is washed with brine
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated in vacuo