2-Fluoro-4-methoxybenzonitrile → 2-Fluoro-4-hydroxybenzonitrile

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-fluoro-4-methoxy-benzonitrile (500 mg, 0.246 mmol) and pyridine hydrochloride (2.0 g, 17.2 mmol) is heated at 170° C. for 5 hours. The reaction is partitioned between ethyl acetate and 1N hydrochloric acid. The organic phase is washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford 2-fluoro-4-hydroxy-benzonitrile.

Provenance & Evidence