Isobutyryl chloride → HCID 178482774, compound

HRID 2209815Notes

Reaction equation

HRID 2209815 reaction equation
[Cl:1][C:2]1[CH:35]=[CH:34][C:5]([C:6]([N:8]([C@H:10]2[CH2:15][CH2:14][C@H:13]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][O:25][C:26](=[O:30])[CH:27](C)C)=[CH:18][C:17]=3[CH2:31][NH:32][CH3:33])[CH2:12][CH2:11]2)[CH3:9])=[O:7])=[CH:4][CH:3]=1.ClC1C=CC(C(N([C@H]2CC[C@H](C3C=CC(CCCO)=CC=3CNC)CC2)C)=O)=CC=1.C(Cl)(=O)C(C)C>>[C:26]([O:25][CH2:24][CH2:23][CH2:22][C:19]1[CH:20]=[CH:21][C:16]([C@H:13]2[CH2:12][CH2:11][C@H:10]([N:8]([C:6](=[O:7])[C:5]3[CH:34]=[CH:35][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH3:9])[CH2:15][CH2:14]2)=[C:17]([CH2:31][NH:32][CH3:33])[CH:18]=1)(=[O:30])[CH3:27]

Participants

4

Reactant 3

HCID 62325Isobutyryl chlorideHCID 178482766HCID 178482766, compoundHCID 178482778HCID 178482778, compound

Product 1

HCID 178482774HCID 178482774, compound

Procedure

trans-N-(4-chlorobenzoyl)-N-methyl-4-[4-(3-isobutyryloxypropyl)methylaminomethylphenyl]-cyclohexylamine from trans-N-(4-chlorobenzoyl)-N-methyl-4-[4-(3-hydroxypropyl)methylaminomethylphenyl]cyclohexylamine and isobutyrylchloride. Melting point: 79°-81° C.

Sources & evidence

ORD record
ord-741f4bdc255e4cb5a9e9f7f993b37906
Source dataset
uspto-grants-1995_10
Patent number
US05455273

Reaction notes

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