4-Pentynoic acid → HCID 178447356, compound

HRID 2209822Notes

Reaction equation

HRID 2209822 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C@H:11]2[CH2:16][CH2:15][C@H:14]([NH:17][CH3:18])[CH2:13][CH2:12]2)=[C:7]([CH2:19][NH:20][CH3:21])[CH:6]=1.[C:22]([OH:28])(=O)[CH2:23][CH2:24][C:25]#[CH:26]>>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C@H:11]2[CH2:16][CH2:15][C@H:14]([N:17]([CH3:18])[C:22](=[O:28])[CH2:23][CH2:24][C:25]#[CH:26])[CH2:13][CH2:12]2)=[C:7]([CH2:19][NH:20][CH3:21])[CH:6]=1

Participants

3

Reactant 2

HCID 224644-Pentynoic acidHCID 178482764HCID 178482764, compound

Product 1

HCID 178447356HCID 178447356, compound

Procedure

from trans-4-[4-(3-hydroxypropyl)methylaminomethyl-phenyl)-N-methylcyclohexylamine, N,N'-carbonyldiimidazole and 4-pentynoic acid. Oil. Rf value: 0.66 (alumina/ethyl acetate/methanol=100:1, v:v).

Sources & evidence

ORD record
ord-1f1a235d14dd4e8ead2c17638bcd94da
Source dataset
uspto-grants-1995_10
Patent number
US05455273

Reaction notes

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