反应详情

A mixture of 4-[2-[4-(1H-indole-3-yl)-1-piperidinyl]ethyl]-2(1H)-quinolinone (III-2) (500 mg, 1.35 mmol) in methanol (15 ml) and tetrahydrofuran (25 ml) was refluxed until solids were dissolved. Under the same conditions, maleic acid (172.9 mg, 1.49 mmol) in methanol (10 ml) was added thereto and then the solvent was distilled off from the reaction mixture. The residue was crystallized with acetone and then recrystallized from acetone-methanol to give the desired product (III'-2-b) (404 mg) as pale yellow crystals (138°-141 ° C., yield 61.4%)

1. temperaturewas refluxed until solids
2. dissolutionwere dissolved
3. distillationthe solvent was distilled off from the reaction mixture
4. customThe residue was crystallized with acetone
5. customrecrystallized from acetone-methanol