Dabco → HCID 19379735, compound

HRID 2209993Notes

Reaction equation

HRID 2209993 reaction equation
[Cl:1][C:2]1[C:3](F)=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]([CH2:12][CH3:13])[CH:9]=[C:8]([C:14]([OH:16])=[O:15])[C:7]2=[O:17].[NH2:19][CH:20]1[CH:28]=[CH:27][CH:26]([CH3:29])[CH:25]2[CH:21]1[CH2:22][NH:23][CH2:24]2.N12CCN(CC1)CC2>CS(C)=O>[NH2:19][CH:20]1[CH:28]=[CH:27][CH:26]([CH3:29])[CH:25]2[CH:21]1[CH2:22][N:23]([C:3]1[C:2]([Cl:1])=[C:11]3[C:6]([C:7](=[O:17])[C:8]([C:14]([OH:16])=[O:15])=[CH:9][N:10]3[CH2:12][CH3:13])=[CH:5][CH:4]=1)[CH2:24]2

Participants

5

Reactant 3

HCID 9237DabcoHCID 15283251HCID 15283251, compoundHCID 19379776HCID 19379776, compound

Product 1

HCID 19379735HCID 19379735, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

270 mg (1 mmol) of 8-chloro-1-ethyl-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid together with 180 mg (1.2 mmol) of 4-amino-7-methyl-1,3,3a,4,7,7a-hexahydroisoindole and 224 mg (2 mmol) of 1,4-diazabicyclo[2.2.2]octane are heated for three hours at 100° C. in 10 ml of dimethyl sulphoxide.

Sources & evidence

ORD record
ord-b2c3f1438b854097bd78c5e994c55ade
Source dataset
uspto-grants-1995_10
Patent number
US05457104

Reaction notes

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