Benzophenone oxime → benzophenone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-alpha-methylbenzyl}-oxime

HRID 2210037Notes

Reaction equation

HRID 2210037 reaction equation
[C:1](=[N:14][OH:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH:17]([C:19]1[CH:24]=[CH:23][C:22]([S:25][C:26]2[CH:27]=[C:28]([C:33]3([O:39][CH3:40])[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[CH:29]=[C:30]([F:32])[CH:31]=2)=[CH:21][CH:20]=1)[CH3:18]>>[F:32][C:30]1[CH:29]=[C:28]([C:33]2([O:39][CH3:40])[CH2:34][CH2:35][O:36][CH2:37][CH2:38]2)[CH:27]=[C:26]([S:25][C:22]2[CH:21]=[CH:20][C:19]([CH:17]([O:15][N:14]=[C:1]([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH3:18])=[CH:24][CH:23]=2)[CH:31]=1

Participants

3

Reactant 2

HCID 11324Benzophenone oximeHCID 193799314-{3-[4-(1-Chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran

Product 1

HCID 19379943benzophenone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-alpha-methylbenzyl}-oximeYield 38%

Conditions

Temperature
60 °C

Procedure

Using an analogous procedure to that described in Example 1 except that the reactants were heated to 60° C. for 2 hours, benzophenone oxime was reacted with 4-{3-[4-(1-chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran to give benzophenone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α-methylbenzyl}-oxime as an oil in 38% yield.

Sources & evidence

ORD record
ord-6cdcd306af894bc9ae290ec37485ca50
Source dataset
uspto-grants-1995_10
Patent number
US05457125

Reaction notes

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