2-Thiazoline → (2-((Dimethylamino)methyl)thiazol-4-yl)methanol

HRID 2210239Notes

Reaction equation

HRID 2210239 reaction equation
O[C:2]1([CH2:11]Cl)[CH2:6][S:5][C:4]([CH2:7][N:8]([CH3:10])[CH3:9])=[N:3]1.CC(C)([O-:16])C.[K+].S1CCN=C1>C(O)(C)(C)C>[CH3:9][N:8]([CH2:7][C:4]1[S:5][CH:6]=[C:2]([CH2:11][OH:16])[N:3]=1)[CH3:10]

Participants

5

Reactant 3

HCID 1202692-ThiazolineHCID 103307024-Thiazolol, 4-(chloromethyl)-2-[(dimethylamino)methyl]-4,5-dihydro-HCID 23665647Potassium tert-butoxide

Product 1

HCID 1838020(2-((Dimethylamino)methyl)thiazol-4-yl)methanol

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

The process of Example 5 was repeated using 5.0 g (0.24 mol) of 4-hydroxy-4-chloromethyl-2-(dimethylaminomethyl)thiazoline, 25 ml of t-butylalcohol and 2.69 g (0.024 mol) of potassium t-butoxide. The HPLC assay set forth in Example 3 indicated that 90% of the thiazoline substrate had converted to the desired titled product.

Sources & evidence

ORD record
ord-8d519d4252d64570bba575e7065dfda7
Source dataset
uspto-grants-1995_10
Patent number
US05457206

Reaction notes

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