HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiazoline → (2-((Dimethylamino)methyl)thiazol-4-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiazoline | HCID 120269 | — |
| Reactant | 4-Thiazolol, 4-(chloromethyl)-2-[(dimethylamino)methyl]-4,5-dihydro- | HCID 10330702 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | (2-((Dimethylamino)methyl)thiazol-4-yl)methanol | HCID 1838020 | — |
Reaction Steps
The process of Example 5 was repeated using 5.0 g (0.24 mol) of 4-hydroxy-4-chloromethyl-2-(dimethylaminomethyl)thiazoline, 25 ml of t-butylalcohol and 2.69 g (0.024 mol) of potassium t-butoxide. The HPLC assay set forth in Example 3 indicated that 90% of the thiazoline substrate had converted to the desired titled product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05457206 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-8d519d4252d64570bba575e7065dfda7 |
| Source note | uspto-grants-1995_10 |