Hydrogen Bromide → HCID 19974131, compound

HRID 2210318Notes

Reaction equation

HRID 2210318 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[O:4][C:5]([CH3:11])=[C:6]([C:8](=[O:10])[CH3:9])[N:7]=1.[BrH:14].BrBr>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[O:4][C:5]([CH3:11])=[C:6]([C:8](=[O:10])[CH2:9][Br:14])[N:7]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 19974323HCID 19974323, compound

Product 1

HCID 19974131HCID 19974131, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent3×

Conditions

Temperature
80 °C

Procedure

5.8 g (0.02 mol) of 2-Trifluoromethyl-5-methyl-4-acetyl-oxazole are dissolved in 30 ml of glacial acetic acid, and 3 ml of a 33% strength solution of hydrogen bromide in glacial acetic acid are added. The mixture is heated to 80° C. and, over the course of 1 hour, a solution of 3.2 g (0.02 mol) of bromine in 10 ml of glacial acetic acid is added. After a further 30 minutes the glacial acetic acid is removed. The residue which remains is a dark oil which is reacted further as the crude product.

Workup

  1. customAfter a further 30 minutes the glacial acetic acid is removed
  2. customis reacted further as the crude product

Sources & evidence

ORD record
ord-9eb12fa451c74c4f9b4c4500492f77a9
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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