2-(2-Methyl-thiazol-4-yl)morpholin-5-one → 2-(2-Methyl-1,3-thiazol-4-yl)morpholine

HRID 2210324Notes

Reaction equation

HRID 2210324 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]2[O:12][CH2:11][C:10](=O)[NH:9][CH2:8]2)[N:6]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(Cl)(Cl)Cl.CO.N>>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]2[O:12][CH2:11][CH2:10][NH:9][CH2:8]2)[N:6]=1

Participants

4

Reactant 3

HCID 199743562-(2-Methyl-thiazol-4-yl)morpholin-5-oneHCID 21226445Aluminium lithium hydrideHCID 21866414Chloroform methanol ammonia

Product 1

HCID 199741992-(2-Methyl-1,3-thiazol-4-yl)morpholine

Procedure

Prepared analogously to Example O by reduction of 2-(2-methyl-thiazol-4-yl)morpholin-5-one with lithium aluminium hydride and purification of the base on a silica gel column with chloroform/methanol/ammonia =93:7:0.7 as eluant.

Sources & evidence

ORD record
ord-8f926dfda0e14095b690045022b07f85
Source dataset
uspto-grants-1995_10
Patent number
US05457205

Reaction notes

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