Methylamine → 2-(Methylamino)pyridine-3-sulfonamide

HRID 2210420Notes

Reaction equation

HRID 2210420 reaction equation
Cl[C:2]1[C:7]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][NH2:13]>>[CH3:12][NH:13][C:2]1[C:7]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 122344452-chloropyridine-3-sulfonamide

Product 1

HCID 124951952-(Methylamino)pyridine-3-sulfonamide

Procedure

10 g of 2-chloropyridine-3-sulfonamide (obtained in Stage A of Preparation 6) are dissolved in 100 cm3 of 40% aqueous methylamine solution and the solution is introduced into a sealed tube. The tube is placed at 150° C. for 18 hours. After cooling, the reaction mixture is concentrated under vacuum (rotary evaporator) to a volume of 30 cm3. The crystalline precipitate corresponding to the title compound is collected on a filter, washed with water and dried.

Workup

  1. additionthe solution is introduced into a sealed tube
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture is concentrated under vacuum (rotary evaporator) to a volume of 30 cm3
  4. customThe crystalline precipitate corresponding to the title compound is collected on a filter
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-f20e352cd68a42d2919010920f79ffe3
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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